What is Regenerative Medicine? 3 Key Benefits for Health

Regenerative medicine is a branch of medicine that focuses on repairing, replacing or regenerating damaged cells, tissues and organs. This method aims to address both symptoms and root causes of illness by fixing the structure and function of damaged tissues. Regenerating tissues and organs can now treat many diseases in ways we never thought possible before.

In addition to addressing existing pathologies, regenerative medicine is proactively exploring strategies to strengthen and revitalize tissues before significant damage occurs. This healthcare approach could help prevent certain diseases, improving overall health and wellness by reducing chronic and degenerative conditions.

Potential to treat incurable diseases

Regenerative medicine holds promise for diseases that are currently difficult to cure, such as certain cancers, Parkinson's, Alzheimer's, and chronic heart conditions. In addition, regenerative medicine can offer solutions for severe traumatic injuries, extensive burns, and tissue repair in autoimmune diseases. The ability to create new healthy tissues offers opportunities to improve patients' lives by helping them regain functions lost to disease or injury.

In addition, regenerative medicine can reduce the need for donor organ transplants, which are limited and often require patients to wait a long time. By being able to regenerate tissues and organs in the laboratory, demand could be met and organ transplant rejection problems avoided.

Research and development in this field is advancing rapidly. This is due to advances in biotechnology, tissue engineering and the understanding of regeneration mechanisms at the molecular and cellular level. With all this progress, regenerative medicine promises to revolutionize healthcare, offering new hope for patients and transforming medical practices in the near future.

Main areas of regenerative medicine

  • Cellular therapies: These use stem cells and other types of cells to regenerate damaged tissues. These therapies are being developed to treat a variety of conditions, from spinal cord injuries to heart disease. Stem cells, in particular, have the ability to differentiate into different cell types, making them extremely versatile for regenerative treatments.
  • Tissue engineering: This area combines cells, engineering methods and suitable materials to create functional tissues. For example, cells can be cultured to form tissues that can be used in transplantation. This technique is especially promising for the creation of artificial organs that can replace damaged ones.
  • Gene-based regenerative medicine: This involves the use of gene therapy techniques to correct genetic defects and stimulate tissue regeneration. Advanced technologies such as CRISPR-Cas9 allow precise gene editing, offering potential solutions for genetic and chronic diseases.

Advances in gene editing

Gene therapy can directly correct mutations in a patient’s DNA, offering a durable solution for many genetic diseases. For example, in inherited diseases such as cystic fibrosis, correcting the mutation responsible can restore normal function to the affected cells. In addition, gene therapy can be used to modify immune system cells, making them more effective in the fight against cancer and other diseases.

On the other hand, gene-based regenerative medicine is advancing thanks to gene editing, which is opening up new possibilities. By correcting genetic mutations directly in the patient's cells, the root cause of many diseases, rather than just their symptoms, can be treated. One example of gene-editing technology is CRISPR-Cas9, which allows precise changes to be made to DNA to correct genetic mutations that cause serious diseases.

Gene therapies are being used to modify immune system cells to make them more effective in fighting cancer and other diseases. Advances in gene delivery, gene editing and safety are bringing gene-based regenerative medicine closer to reality

TECNIC's role in regenerative medicine

TECNIC is committed to supporting the advancement of regenerative medicine by providing advanced biotechnological solutions. Our range of products, from bioreactors to Tangential Flow Filtration systems, is designed to support every stage of the research and development process.

  • Bioreactors: Precisely control the cell culture environment to facilitate the growth and differentiation of stem cells. We design our bioreactors to optimize culture conditions, which is essential for developing effective cell therapies.
  • Tangential Flow Filtration: We provide filtration solutions to maintain the purity and quality of biotech products for medical use. TFF systems are important for making drugs and regenerative therapies safe and effective.
  • Bioprocess Supplies: We provide a wide range of supplies that optimize efficiency and effectiveness in laboratories and production plants. Our products, from culture media to reagents, are made for researchers in regenerative medicine to use.

The potential of regenerative medicine is immense. At TECNIC, we are proud to be part of this change. We help the scientific community and start-ups to improve. At TECNIC we are dedicated to driving this promising field forward, supporting the scientific community and startups to accelerate progress and bring breakthroughs to patients faster.

Regenerative Medicine FAQ

Frequently Asked Questions (FAQ)

What is regenerative medicine?

It is a medical approach that repairs or regenerates damaged cells, tissues, or organs to restore normal function.

What diseases can regenerative medicine treat?

It can help treat chronic conditions, injuries, burns, heart disease, neurological disorders, and some types of cancer.

How does regenerative medicine work?

It uses cells, bioengineering, and gene editing to repair or replace damaged tissues and restore their function.

What are the main techniques used?

Cellular therapy, tissue engineering, gene-based therapies, and bioprocessing technologies.

What are the benefits of regenerative medicine?

It offers personalized treatments, faster recovery, reduced need for organ transplants, and long-term health improvements.

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Cassette

We understand the importance of flexibility and efficiency in laboratory processes. That's why our equipment is designed to be compatible with Cassette filters, an advanced solution for a variety of filtration applications. Although we do not manufacture the filters directly, our systems are optimized to take full advantage of the benefits that Cassette filters offer.

Cassette filters are known for their high filtration capacity and efficiency in separation, making them ideal for ultrafiltration, microfiltration, and nanofiltration applications. By integrating these filters into our equipment, we facilitate faster and more effective processes, ensuring high-quality results.

Our equipment, being compatible with Cassette filters, offers greater versatility and adaptability. This means you can choose the filter that best suits your specific needs, ensuring that each experiment or production process is carried out with maximum efficiency and precision.

Moreover, our equipment stands out for its 100% automation capabilities. Utilizing advanced proportional valves, we ensure precise control over differential pressure, transmembrane pressure, and flow rate. This automation not only enhances the efficiency and accuracy of the filtration process but also significantly reduces manual intervention, making our systems highly reliable and user-friendly.

Hollow Fiber

We recognize the crucial role of flexibility and efficiency in laboratory processes. That's why our equipment is meticulously designed to be compatible with Hollow Fiber filters, providing an advanced solution for a broad spectrum of filtration applications. While we don't directly manufacture these filters, our systems are finely tuned to harness the full potential of Hollow Fiber filters.

Hollow Fiber filters are renowned for their exceptional performance in terms of filtration efficiency and capacity. They are particularly effective for applications requiring gentle handling of samples, such as in cell culture and sensitive biomolecular processes. By integrating these filters with our equipment, we enable more efficient, faster, and higher-quality filtration processes.

What sets our equipment apart is its 100% automation capability. Through the use of sophisticated proportional valves, our systems achieve meticulous control over differential pressure, transmembrane pressure, and flow rate. This level of automation not only boosts the efficiency and precision of the filtration process but also significantly diminishes the need for manual oversight, rendering our systems exceptionally reliable and user-friendly.

Contact General

Cellular configuration

The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.

Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture. 

Cellular configuration

The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.

Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture. 

Cellular configuration

The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.

Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture. 

Microbial configuration

The microbial configuration of the eLab Advanced is equipped with a Rushton turbine specifically designed for high-oxygen-demand processes such as bacterial and yeast fermentations. The radial-flow impeller generates strong mixing and intense gas dispersion, promoting high oxygen transfer rates and fast homogenization of nutrients, antifoam and pH control agents throughout the vessel. This makes it particularly suitable for robust microbial strains operating at elevated agitation speeds and aeration rates.

Operators can adjust agitation and gas flow to reach the required kLa while maintaining consistent mixing times, even at high cell densities. This configuration is an excellent option for users who need a powerful, reliable platform to develop and optimize microbial processes before transferring them to pilot or production scales.

Cellular configuration

The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.

Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture. 

Technical specifications

Materials and finishes

Typical
  • Product-contact parts: AISI 316L (1.4404), typical Ra < 0.4 µm (16 µin)
  • Non-contact parts/skid: AISI 304/304L
  • Seals/elastomers: platinum-cured silicone, EPDM and/or PTFE (material set depends on selection)
  • Elastomers compliance (depending on selected materials): FDA 21 CFR 177.2600 and USP Class VI
  • Surface treatments: degreasing, pickling and passivation (ASTM A380 and ASTM A968)
  • Roughness control on product-contact surfaces

Design conditions

Pressure & temperature

Defined considering non-hazardous process fluids (PED group 2) and jacket steam/superheated water (PED group 5), depending on configuration and project scope.

Reference design envelope
ModeElementWorking pressure (bar[g])Working pressure (psi[g])T max (°C / °F)
ProcessVessel0 / +2.50 / +36.3+90 / 194
ProcessJacket0 / +3.80 / +55.1+90 / 194
SterilisationVessel0 / +2.50 / +36.3+130 / 266
SterilisationJacket0 / +3.80 / +55.1+150 / 302
Jacket working pressure may also be specified as 0 / +4 bar(g) (0 / +58.0 psi[g]) depending on design selection; final values are confirmed per project.

Pressure control and safeguards

Typical
  • Designed to maintain a vessel pressure set-point typically in the range 0 to 2.5 bar(g)
  • Aseptic operation commonly around 0.2 to 0.5 bar(g) to keep the vessel slightly pressurised
  • Overpressure/underpressure safeguards included per configuration and regulations
  • Pressure safety device (e.g., rupture disc and/or safety valve) included according to configuration

Agitation

Reference ranges
Working volumeMU (Cell culture), referenceMB (Microbial), reference
10 L0 to 300 rpm0 to 1000 rpm
20 L0 to 250 rpm0 to 1000 rpm
30 L0 to 200 rpm0 to 1000 rpm
50 L0 to 180 rpm0 to 1000 rpm

Integrated peristaltic pumps (additions)

Typical

The equipment typically includes 4 integrated variable-speed peristaltic pumps for sterile additions (acid/base/antifoam/feeds). Actual flow depends on selected tubing and calibration.

ParameterTypical valueNotes
Quantity4 units (integrated)In control tower; assignment defined by configuration
Speed0-300 rpmVariable control from eSCADA
Minimum flow0-10 mL/minExample with 0.8 mm ID tubing; depends on tubing and calibration
Maximum flowUp to ~366 mL/minExample with 4.8 mm ID tubing; actual flow depends on calibration
Operating modesOFF / AUTO / MANUAL / PROFILEAUTO typically associated to pH/DO/foam loops or recipe
FunctionsPURGE, calibration, totaliser, PWMPWM available for low flow setpoints below minimum operating level

Gas flow control (microbial reference capacity)

Reference

For microbial culture (MB), gas flow controllers (MFC) are typically sized based on VVM targets. Typical reference VVM range: 0.5-1.5 (to be confirmed by process).

Working volume (L)VVM minVVM maxAir (L/min)O2 (10%) (L/min)CO2 (20%) (L/min)N2 (10%) (L/min)
100.51.55-150.5-1.51-30.5-1.5
200.51.510-301-32-61-3
300.51.515-451.5-4.53-91.5-4.5
500.51.525-752.5-7.55-152.5-7.5
O2/CO2/N2 values are shown as reference capacities for typical gas blending strategies (10% O2, 20% CO2, 10% N2). Final gas list and ranges depend on process and configuration.

Instrumentation and sensors

Typical

Instrumentation is configurable. The following list describes typical sensors integrated in standard configurations, plus common optional PAT sensors.

Variable / functionTypical technology / interfaceStatus (STD/OPT)
Temperature (process/jacket)Pt100 class A RTDSTD
Pressure (vessel/lines)Pressure transmitter (4-20 mA / digital)STD
Level (working volume)Adjustable probeSTD
pHDigital pH sensor (ARC or equivalent)STD
DO (pO2)Digital optical DO sensor (ARC or equivalent)STD
FoamConductive/capacitive foam sensorSTD
Weight / mass balanceLoad cell (integrated in skid)STD
pCO2Digital pCO2 sensor (ARC or equivalent)OPT
Biomass (permittivity)In-line or in-vessel sensorOPT
VCD / TCDIn-situ cell density sensorsOPT (MU)
Off-gas (O2/CO2)Gas analyser for OUR/CEROPT
ORP / RedoxDigital ORPOPT
Glucose / LactatePAT sensorOPT

Automation, software and connectivity

Typical

The platform incorporates TECNIC eSCADA (typically eSCADA Advanced for ePILOT) to operate actuators and control loops, execute recipes and manage process data.

Main software functions
  • Main overview screen with process parameters and trends
  • Alarm management (real-time alarms and historical log) with acknowledgement and comment option
  • Manual/automatic modes for actuators and control loops
  • Recipe management with phases and transitions; parameter profiles (multi-step) for pumps and setpoints
  • Data logging with configurable period and export to CSV; PDF report generation
Common control loops
  • Temperature control (jacket heating/cooling)
  • Pressure control (headspace) with associated valve management
  • pH control via acid/base addition pumps and optional CO2 strategy
  • DO control with cascade strategies (agitation, air, O2, N2) depending on package and configuration
  • Foam control (foam sensor and automatic antifoam addition)
Data integrity and 21 CFR Part 11

Support for 21 CFR Part 11 / EU GMP Annex 11 is configuration- and project-dependent and requires customer procedures and validation (CSV).

Utilities

Reference

Utilities depend on final configuration (e.g., AutoSIP vs External SIP) and destination market (EU vs North America). The following values are typical reference points.

UtilityTypical service / configurationPressureFlow / powerNotes
ElectricalEU base: 400 VAC / 50 Hz (3~)N/AAutoSIP: 12 kW; External SIP: 5 kWNA option: 480 VAC / 60 Hz; cabinet/wiring per NEC/NFPA 70; UL/CSA as required
Process gasesAir / O2 / CO2 / N2Up to 2.5 bar(g) (36.3 psi)According to setpointTypical OD10 pneumatic connections; final list depends on package
Instrument airPneumatic valvesUp to 6 bar(g) (87.0 psi)N/ADry/filtered air recommended
Cooling waterJacket cooling water2 bar(g) (29.0 psi)25 L/min (6.6 gpm)6-10 °C (43-50 °F) typical
Cooling waterCondenser cooling water2 bar(g) (29.0 psi)1 L/min (0.26 gpm)6-10 °C (43-50 °F) typical
Steam (External SIP)Industrial steam2-3 bar(g) (29.0-43.5 psi)30 kg/h (66 lb/h)For SIP sequences
Steam (External SIP)Clean steam1.5 bar(g) (21.8 psi)8 kg/h (18 lb/h)Depending on plant strategy

Compliance and deliverables

Typical

Depending on destination and project scope, the regulatory basis may include European Directives (CE) and/or North American codes. The exact list is confirmed per project and stated in the Declaration(s) of Conformity when applicable.

ScopeEU (typical references)North America (typical references)
Pressure equipmentPED 2014/68/EUASME BPVC Section VIII (where applicable)
Hygienic designHygienic design good practicesASME BPE (reference for bioprocessing)
Machine safetyMachinery: 2006/42/EC (until 13/01/2027) / (EU) 2023/1230OSHA expectations; NFPA 79 (industrial machinery) - project dependent
Electrical / EMCLVD 2014/35/EU; EMC 2014/30/EUNEC/NFPA 70; UL/CSA components and marking as required
Materials contactEC 1935/2004 + EC 2023/2006 (GMP for materials) where applicableFDA 21 CFR (e.g., 177.2600 for elastomers) - materials compliance
Software / CSVEU GMP Annex 11 (if applicable)21 CFR Part 11 (if applicable)
Standard documentation package
  • User manual and basic operating instructions
  • P&ID / layout drawings as per project scope
  • Material certificates and finish/treatment certificates (scope dependent)
  • FAT report (if included in contract)
Optional qualification and commissioning services
  • SAT (Site Acceptance Test)
  • IQ / OQ documentation and/or execution (scope agreed with customer)
  • CSV support package for regulated environments (ALCOA+ considerations, backups, time synchronisation, etc.)

Ordering and configuration

Project-based

ePILOT BR is configured per project. To define the right MU/MB package, volumes and options (utilities, sensors, software and compliance), please contact TECNIC with your URS or request the configuration questionnaire.

The information provided above is for general reference only and may be modified, updated or discontinued at any time without prior notice. Values and specifications are indicative and may vary depending on project scope, configuration and applicable requirements. This content does not constitute a binding offer, warranty, or contractual commitment. Any final specifications, deliverables and acceptance criteria will be confirmed in the corresponding quotation, technical documentation and/or contract documents.

Cellular configuration

The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.

Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture. 

Technical specifications

[contact-form-7 id="c5c798c" title="ePilot BR configuration questionnaire"]

Cellular configuration

The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.

Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture. 

Technical specifications

Models and working volumes

Tank

The ePlus Mixer platform combines an ePlus Mixer control tower with Tank frames and eBag 3D consumables. Tank can be supplied in square or cylindrical configurations (depending on project) to match the bag format.

Tank modelNominal volumeMinimum volume to start agitation*
Tank 50 L50 L15 L
Tank 100 L100 L20 L
Tank 200 L200 L30 L
Tank 500 L500 L55 L
*Values based on agitation start interlocks per tank model. Final performance depends on the selected eBag 3D, fluid properties and configuration.

Design conditions and operating limits

Reference

Reference limits are defined for the ePlus Mixer and the Tank. It is recommended to validate the specific limits of the selected eBag 3D and single-use sensors for the customer’s process.

ElementOperating pressureMaximum pressure (safety)Maximum working temperature
ePlus Mixer (control tower)ATM0.5 bar(g)90 °C
TankATM0.5 bar(g)45 °C
Jacket (if applicable)N/A1.5 barDepends on utilities / scope
The 0.5 bar(g) limit is associated with the equipment design, the circuit is protected by a safety valve. Confirm final limits on the equipment nameplate and project specification.

Materials and finishes

Typical
  • Control tower housing and frame: stainless steel 304
  • Product-contact metallic hard parts (if applicable): stainless steel 316 (defined in project manufacturing documentation)
  • Non-product-contact metallic parts: stainless steel 304
  • eBag consumable: single-use polymer (supplier dependent, gamma irradiation / sterilisation per specification)
  • Vent filters: PP (polypropylene), per component list
For GMP projects, the recommended documentation package includes material certificates, surface finish certificates (Ra if applicable) and consumable sterility/irradiation certificates.

Agitation system

Magnetic

Non-invasive magnetic agitation, the impeller is integrated in the eBag 3D Mixer format, avoiding mechanical seals. Agitation speed is controlled from the HMI, with start interlocks linked to the tank model and minimum volume.

Reference speed range
  • Typical agitation range: 120 to 300 rpm (configuration dependent)
  • Magnetic drive motor (reference): Sterimixer SMA 85/140, 50 Hz, 230/400 V, 0.18 kW
  • Gear reduction (reference): 1:5
  • Actuation (reference): linear actuator LEYG25MA, stroke 30–300 mm, speed 18–500 mm/s (for positioning)
Final rpm and mixing performance depend on tank size, bag format and process requirements.

Weighing and volume control

Integrated

Weight and derived volume control are performed using 4 load cells integrated in the tank frame legs and a weight indicator. Tare functions are managed from the HMI to support preparation steps and additions by mass.

ComponentReference modelKey parameters
Load cells (x4)Mettler Toledo SWB505 (stainless steel)550 kg each, output 2 mV/V, IP66
Weight indicatorMettler Toledo IND360 DINAcquisition and HMI display, tare and “clear last tare”
For installation engineering, total floor load should consider product mass + equipment mass + margin (recommended ≥ 20%).

Pumps and fluid handling

Standard

The platform includes integrated pumps for additions and circulation. Final tubing selection and calibration define the usable flow range.

Included pumps (reference)
  • 3 integrated peristaltic pumps for additions (acid/base/media), with speed control from HMI
  • 1 integrated centrifugal pump for circulation / transfer (DN25)
Peristaltic pumps (reference)
ParameterReferenceNotes
Quantity3 unitsIntegrated in the control tower
Pump headHYB101 (Hygiaflex)Example tubing: ID 4.8 mm, wall 1.6 mm
Max speed300 rpmSpeed control reference: 0–5 V
Max flow (example)365.69 mL/minDepends on tubing and calibration
Centrifugal pump (reference)
ParameterReference
ModelEBARA MR S DN25
Power0.75 kW
FlowUp to 42 L/min
PressureUp to 1 bar
For circulation and sensor loops, the eBag 3D format can include dedicated ports (depending on the selected consumable and application).

Thermal management (optional jacket)

Optional

Tank can be supplied with a jacket (single or double jacket options). The thermal circuit includes control elements and a heat exchanger, enabling temperature conditioning depending on utilities and project scope.

  • Jacket maximum pressure (reference): 1.5 bar
  • Thermal circuit safety: pressure regulator and safety valve (reference set-point 0.5 bar(g))
  • Heat exchanger (reference): T5-BFG, 12 plates, alloy 316, 0.5 mm, NBRP
  • Solenoid valves (reference): SMC VXZ262LGK, 1", DC 24 V, 10.5 W
  • Jacket sequences: fill / empty / flush (scope dependent)
The tank maximum temperature may depend on the thermal circuit and consumable limits. Confirm final values with the selected eBag 3D specification.

Instrumentation and sensors

Optional SU

Single-use sensors can be integrated via dedicated modules. The following references describe typical sensors and interfaces listed in the datasheet.

VariableReference modelInterface / protocolSupplyOperating temperatureIP
pHOneFerm Arc pH VP 70 NTC (SU)Arc Module SU pH, Modbus RTU7–30 VDC5–50 °CIP67
ConductivityConducell-P SU (SU)Arc Module Cond-P SU, Modbus RTU7–30 VDC0–60 °CIP64
TemperaturePt100 ø4 × 52 mm, M8 (non-invasive)Analog / acquisition moduleProject dependentProject dependentProject dependent
Measurement ranges and final sensor list depend on the selected single-use components and project scope.

Automation, software and data

Standard + options

The ePlus SUM control tower integrates an industrial PLC and touch HMI. Standard operation supports Manual / Automatic / Profile modes, with optional recipe execution depending on selected software scope.

Software scope (reference)
  • Standard: eBASIC (base HMI functions)
  • Optional: eSCADA Basic or eSCADA Advanced (project dependent)
  • Trends, alarms and profiles, profiles up to 100 steps (depending on scope)
  • Data retention (reference): up to 1 year
Connectivity (reference)
  • Industrial Ethernet and integrated OPC server (included)
  • Remote access option (project dependent)

Utilities and facility interfaces

Typical

Installation requirements depend on jacket and temperature scope and the customer layout. The following values are typical references.

UtilityPressureFlowConnectionsNotes
Electrical supplyN/AReference: 18 A380–400 VAC, 3~ + N, 50 HzConfirm per final configuration and destination market
EthernetN/AN/ARJ45OPC server, LAN integration
Tap water2.5 barN/A1/2" (hose connection)Jacket fill and services, tank volume about 25 L
Cooling water2–4 bar10–20 L/min2 × 3/4" (hose connection)Heat exchanger and jacket cooling
Process air2–4 barN/A1/2" quick couplingUsed for jacket emptying
DrainN/AN/A2 × 3/4" (hose connection)For draining
ExhaustN/AN/AN/AOptional (depending on project)
Stack light (optional)N/AN/AN/A3-colour indication, as per scope
During FAT, verify in the installation checklist that the available utilities match the selected configuration and scope.

Documentation and deliverables

Project-based

Deliverables depend on scope and project requirements. The following items are typical references included in the technical documentation package.

  • Datasheet and user manual (HMI and system operation)
  • Electrical schematics, PLC program and backup package (scope dependent)
  • P&ID, layout and GA drawings (PDF and/or CAD formats, project dependent)
  • Factory Acceptance Test (FAT) protocol and FAT report (as per contract)
  • Installation checklist
  • Material and consumable certificates, as required for regulated projects (scope dependent)
On-site services (SAT, IQ/OQ) and extended compliance packages are optional and defined per project.

Ordering and configuration

Contact

The ePlus Mixer scope is defined per project. To select the right tank size, bag format, sensors and optional jacket and software, please share your URS or request the configuration questionnaire.

The information provided above is for general reference only and may be modified, updated or discontinued at any time without prior notice. Values and specifications are indicative and may vary depending on project scope, configuration and applicable requirements. This content does not constitute a binding offer, warranty, or contractual commitment. Any final specifications, deliverables and acceptance criteria will be confirmed in the corresponding quotation, technical documentation and/or contract documents.

Cellular configuration

The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.

Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture. 

Scale

Bioreactors engineered for smooth scale-up

From S to XL, with a clear scale path

Move from laboratory to pilot and production with a structured range: eLab (0.5–10 L), ePilot (30–50 L), eProd (100–2000 L). Scale with clearer continuity across platforms, supporting the same key control priorities and configuration paths for a smoother transition between volumes.